|
|
|
| A synthesis method of denatonium saccharid |
| Yan Liang, Jiang Xiaoping, Zhu Xiaopeng, Fu Luoping |
| ZheJiang Synose Tech Corpration Ltd., Jinhua 321075, China |
|
|
|
|
Abstract Denatonium saccharide is one of the two bitterest substances known in the world. By adding it to methanol, industrial oils and toxic household and vehicular agricultural chemicals that are easily ingested, it gives them a bitter taste and prevents people from ingesting it.Denatonium saccharide was prepared from denatonium benzoate aqueous solution and saccharin sodium with distilled water through one-step post-treatment. This method has the advantages of saving a lot of solvent, reducing the production cost, simplifying the synthesis process, reduc the discharge of waste liquid, and is more conducive to industrial production and improving production efficiency.
|
|
|
|
|
|
| [ 1 ] 王玉兰. 糖精苄铵酰胺的合成方法：CN，99126300.6[ P ]. 1999-12-14.
[ 2 ] 王玉兰. 苯酸苄铵酰胺作为苦味剂的应用：CN，98101236.1 [ P ].1998-04-01.
[ 3 ] 吕 艳. 苯酸苄铵酰胺（苦精）的合成方法： CN，2014106
35895.6 [ P ].2014-11-13.
[ 4 ] 严晓阳. 苯酸苄铵酰胺高效液相色谱分析方法的研究[ J ]. 浙江化工，2004，9（ 6 ）：4-7.
[ 5 ] 廖正根，钟文静，蒋且英，等. 苦味形成机理与中药苦味掩味技术的研究概况[ J ]. 时珍国医国药，2008，19（ 5 ）：1 276.
[ 6 ] 任树龙，王亚静，郑银基，等. 基于苦味产生机制的掩味策略与评价[ J ]. 中南药学，2014，12（ 6 ）：562 - 566.
[ 7 ] 刘 娟. 掩味技术在儿科常用口服固体制剂的应用[ J ]. 天津药学，2014，26（ 1 ）：59 - 62.
[ 8 ] Yan Y D, Woo J S, Kang J H, et al. Preparttion and evaluation of taste-masked donepezil hydroehloride orally disintegrating tablets [ J ]. Biol Pharm Bull, 2010, 33（ 8 ）：1 364-1 370.
[ 9 ] 李学林.苦味抑制剂的研究进展[ J ].中国实验方剂学杂志，2012，18（ 21 ）：335 - 338.
[ 10 ] Barre A, Damme E J M, Peumans W J, Roune P. Curculin, a sweet-
tasting and taste-modifying protein，is a non-functional mannose-
binding lection[ J ]. Plant Molecular Biology, 1997, 33: 691.
[ 11 ] 刘西瑛，刘云清. 大环内酯类抗生素苦味的掩盖方法及配方研究[ J ]. 北京医科大学学报，1997，29（ 3 ）：136. |
|
|
|
