7-氨基-3-甲氧基甲基-3-头孢烯-4-甲酸的合成

doi:10.19286/j.cnki.cci.2019.11.034

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Abstract

7-Amino-3-methoxymethyl-3-cephem-4-carboxylic acid (7-AMCA) is an essential intermediate for the synthesis of cefpodoxime proxetil. At present, the two processes for synthesizing 7-AMCA with 7-amino cefalic acid(7-ACA) or D-7-ACA as raw materials all have defects such as harsh process conditions, difficult solvent recovery, high environmental pressure and low product purity. In order to develop a green preparation process suitable for its industrial production, based on the preparation of 7-AMCA by D-7-ACA, the effects of key raw material dosage, reaction temperature and reaction time on product yield and quality were investigated through experiments. The experimental results show when the reaction temperature is 30 ℃ and the reaction time is 15 min, the ratio of the raw material of trimethyl orthoformate to D-7-ACA is 2∶1, and ammonia is used as the basic crystallization reagent, the obtained 7-AMCA has good properties and high purity, and the process is more conducive to industrial production.

Key words： 7-AMCA D-7-ACA methanesulfonic acid trimethyl orthoformate

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	Articles by authors
	Sun Meiting
	Jiang Pengpeng
	Liang Bingchen
	Wang Yudong

Cite this article:

Sun Meiting,Jiang Pengpeng,Liang Bingchen等. Synthesis of 7-amino-3-methoxymethyl-3-cephem-4-carboxylic acid[J]. CCI, 2019, 42(11): 126-131，160.

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http://www.mtyhg.com.cn/EN/10.19286/j.cnki.cci.2019.11.034 OR http://www.mtyhg.com.cn/EN/Y2019/V42/I11/126

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