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| Study on the synthesis of choline-urea deep eutectic solvent and its kilogram scale-up preparation |
| Feng ShuBo1,2，Wang Shubo2， Hou Xiaoxia1， Zhang Haopeng1， Zhai Qiannan1 |
| 1. Institute of Petroleum and Chemical Engineering, College of Chemical and Pharmaceutical Engineering，Hebei University of Science and Technology， Shijiazhuang, 050018， China； 2. Bayin Guoleng Vocational College, Kuerle 841000, China |
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Abstract The deep eutectic solvent (DES) composed of choline chloride and urea was prepared on kilogram level. The molar ratio effect, temperature and reaction time on physi-chemical properties of the DES were investigated, respectively. Refractive index, conductivity, viscosity of samples and products were measured during the reaction process. A possible chemical structure of the DES was analyzed based on FT-IR infrared spectroscopy spectrum. Experimental results show that the deep eutectic solvent can not be formed for the ratio of choline chloride to urea of 1∶1 for the ratio of choline chloride to urea of 1∶1.5 and 1∶2, and not formed. In the case of the ration of 1∶2, the deep eutectic solvent can be formed at 70, 80 and 90 ℃, and not at 60 ℃. The required time of the reaction is shortened with the increasing temperature. When refractive index is 1.505, the DES exhibits constant properties, which suggested that a stable chemical structure is formed. In addition, water contents in feedstocks and product affect property of DES in some content. A difference of physichemical properties of DES in literatures was clarified. The study provides valuable data for commercial production of DES.
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