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| Optimization of crystallization process of cefuroxime sodium for injection raw powder |
| Li Yaqing, Liu Yalin, Qiao Junhua, Kang Jian, Gu Yifan |
| North China Pharmaceutical Hebei Huamin Pharmaceutical Corporation Ltd., Shijiazhuang 052165, China |
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Abstract Cefuroxime sodium powder is obtained by aseptic packaging of cefuroxime sodium sterile raw material. The crystallization process of cefuroxime sodium is optimized. By comparing sodium bicarbonate with sodium isooctanate, the crystallization temperature, crystallization pH value, stirring strength and crystallization system were optimized, the crystalline form of the product is the same as that of the original product, thereby improving the quality and stability of cefuroxime sodium for injection.
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| [ 1 ] 王金虎. 一锅法合成头孢呋辛钠的工艺研究[ D ]. 湖南大学硕士学位论文，2015，10.
[ 2 ] 李爱军，周雪琴，刘东志. 头孢呋辛钠合成工艺优化[ J ]. 天津大学学报，2007，40（ 11 ）：1 342 - 1 345.
[ 3 ] 郭明辉，赵洪娥. 头孢呋辛钠结晶工艺研究[ J ]. 煤炭与化工，2018，41（ 1 ）：64 - 65.
[ 4 ] 陈兆坤，胡昌勤，沈永嘉. 头孢呋辛钠的氨解研究[ J ]. 中国热带医学，2007，7（ 10 ）：1 770 - 1 771.
[ 5 ] 赵颖颖. 头孢呋辛钠耦合结晶新工艺研究[ D ]. 天津大学， 2012.
[ 6 ] 王慧慧. 头孢呋辛钠反应及结晶过程研究[ D ]. 天津大学，2015. |
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