In order to study the processing technology in increasing the content uniformity of chlorpheniramine maleate in Children＇s acetaminophen alkylamine particles,orthogonal test was adopted in the statistic study of three factors, amount of purified water, wet mixing time,temperature of purified water in the prescription of Children＇s acetaminophen alkylamine particles. Best technological parameter was achieved by optimizing the amount of purified water（ A ）, wet mixing time（ B ）, and the temperature of purified water（ C ） in the prescription.The best combination was A2,B1,C2,i.e,the amount of purified water was 3.8 L,wet mixing time was 8 min，and the temperature of purified water was 40～45 ℃.The results showed that this preparation method could increase the content uniformity of chlorpheniramine maleate in Children＇s acetaminophen alkylamine particles, and optimize the preparation process,improve the quality of product,and improve the production efficiency