As the increasing mining depth and gas emission in Dongpang Mine, needed air and ventilation resistance increased, in order to ensure the stable operation of the mine ventilation system and the safe production of the mine, it is urgent to improve the deep level ventilation system in the mine. In this paper, two schemes for optimizing ventilation system were proposed. In order to ensure the reliability of the optimization effect of the mine ventilation system, the computer network calculation technique was used to select the ventilation optimization scheme. Through the theoretical analysis of ventilation, the main factors affecting the resistance of the mine ventilation system were found out, which provided technical support for the next step of the reform of the mine ventilation system. The downcast shaft scheme was selected as the optimized scheme of ventilation system.