According to the water characteristics of Xingdong Mine Water with high turbidity, oil and water quality varies widely, PAC, PAFC, FeSO4 and PAM of four kinds of water treatment chemicals were selected for coagulation experiments. Experimental results showed that: the best effect was the PAFC and PAM combining dosing; normal water quality condition of PAFC and PAM optimum dosage was 90（mg ·L-1 ） and 1.0 （mg·L-1）, special water quality condition of PAFC and PAM optimum dosage was 200 （mg ·L-1 ） and 2.0 （mg·L-1 ）；the PAFC and PAM combined dosing interval 60 seconds coagulation effect was the best；After coagulating and depositing, the supernatant turbidity was less than 5 NTU, oil less than 5 （mg·L-1 ）.