In order to study the characteristics of resistance loss of high concentration cemented filling material in the pipeline transportation, circular tube tests were carried out under different concentration and different fly ash content, and the value of the resistance loss and the local resistance loss in the pipeline transportation of high density cementing filling slurry pipeline were obtained. The results revealed that the resistance loss of pipeline conveying of high concentration cemented filling slurry was increased with the increase of the concentration of the slurry and with the increase of the content of fly ash, when the slurry concentration increased by 0.5%, the resistance losses will increase 6.17%~21.08%, the loss of local resistance increased 7.48%~12.24%, and when the fly ash content increased by 2%, the resistance loss along the path will increase 6.5%~15.24%, the local resistance loss increased by 2.16%~5.42%.