In view of the defect, small range and inconvenience transmission of single point temperature measurement in the traditional close temperature acquisition system , complex line and high signal noise of temperature measurement in long distance signal transmission system, the remote telemetry method based on the wireless radio frequency communication technology was put forward for multi-point temperature，and the telemetry system of multi-point temperature based on RTX51 and RF905 was designed. The hardware platform of system was built with STC12C5A60S2 development board, NRF905 wireless data transceiver module, TFT LCD screens, the digital temperature sensor DS18B20.The system software was written in C and VC++ programming language. The system was debugged and achieved the preconcert function of the multi-point temperature telemetry. The communication distance of wireless telemetry can reach to 200 m, and the communication was stable and reliable.